Domains

What does it take to build a biologically faithful digital twin of an entire brain? Not a schematic. Not a wiring diagram. A computational object where 139,000 neurons fire, 50 million synapses transmit, and 8,453 cell types express their distinct electrical personalities — all constrained by the actual anatomy. BRAVLi is a literate codebase for reconstructing and simulating the Drosophila connectome. The fruit fly brain is the first organism for which a complete synaptic-resolution wiring diagram exists (the FlyWire dataset). This makes it the ideal testbed for the MayaLucIA approach: start from sparse but high-quality measurements, exploit the interdependencies that physics and biology impose, and grow a dense, simulatable digital twin. ...

Moundains cannot be surmounted except by winding paths. – Gabriel Garcia Marquez In the mountains of truth, you will never climb in vain. – Henry David Thoreau The heart of the mountains is like the heart of our existence. – Peter Matthiessen I will not let my feet touch the ground until I have reached the summit. – Tenzing Norgay ...